Tissue localisation of tetra- and pentabromodiphenyl ether congeners (BDE-47, -85 and -99) in perinatal and adult C57BL mice

The distribution of polybrominated diphenyl ether (PBDE) congeners was followed in C57BL mice. The animals were subjected to whole-body autoradiography using (14)C-labelled 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), 2,2',3,4,4'-pentabromodiphenyl ether (BDE-85) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99). Labelled BDE-85 and -99 were also used in quantitative studies on milk transfer and tissue concentrations during the neonatal period (12-15 days post partum), by use of liquid scintillation technique. The results show that in adult mice the studied PBDEs were effectively taken up, retained in fatty tissues and concentrated in some specific organs, i.e. the liver, adrenal cortex, ovary, lung and (initially) the brain. At longer post-injection time, the concentration in most tissues was considerably lower, and radioactivity was mainly found in fat depots and the liver. No significant difference in distribution between the three studied congeners was observed. Following maternal exposure, the foetal uptake was limited. On the other hand, during lactation a considerable fraction of the dose (about 20% of the studied penta-BDEs) given to the dam was transferred to the offspring. As in several cases the presently observed organ accumulation corresponds with earlier reports on PBDE effects in the same organs, the present results should be taken into consideration in the risk assessment of this compound group.     

Erratum to: Fuelling the English breakfast: hidden energy flows in the Anglo-Danish trade 1870–1913

The 1870–1914 globalization period had profound impacts on the international division of labour, with coal-endowed countries specializing in the production of energy-intensive manufacturing goods and others in the production of agricultural goods. This study analyses the environmental consequences of this specialization, by quantifying the flows of energy and hidden energy embodied in the bilateral trade between the UK, the industrial workshop of the world, and Denmark, a coal-poor country with an agricultural economy. We show that the transformations that occurred in Danish agriculture to meet the growing demand for breakfast foods in the UK required significant quantities of feed and coal. Denmark was a net importer of energy throughout the period and a net importer of hidden energy in 1870. However, by the end of this wave of globalization, Denmark had become a significant net exporter of hidden energy to the UK. This was due both to an increase in its land productivity and to the import of coal, grain and fertilizers from abroad.

     

Personal deposited dose and its influencing factors at several Greek sites: an analysis in respect to seasonal and diurnal variations

Environmental Science and Pollution Research - The deposited dose in the human respiratory tract and its influencing factors were investigated for 8 urban/suburban locations within Greek cities. A...     

Do tailings from the Mariana,MG (Brazil), disaster affect the initial development of millet,maize, and sorghum?

Environmental Science and Pollution Research - The collapse of the Fundão dam in Mariana, MG, in 2015 resulted in the overflow of more than 50 million m3 of mud containing mine tailings,...     

Evaluation of biotechnological processes to obtain ethanol from recycled paper sludge

Journal of Material Cycles and Waste Management - Finding innovative solutions to manage waste and to expand the production of biofuels are some of the current challenges. Pulp and paper sectors,...     

Using DNA barcoding to track seafood mislabeling in Los Angeles restaurants

Seafood mislabeling is common in both domestic and international markets. Studies on seafood fraud often report high rates of mislabeling (e.g., >70%), but these studies have been limited to a single sampling year, which means it is difficult to assess the impact of stricter governmental truth‐in‐labeling regulations. We used DNA barcoding to assess seafood labeling in 26 sushi restaurants in Los Angeles over 4 years. Seafood from 3 high‐end grocery stores were also sampled (n = 16) in 2014. We ordered 9 common sushi fish from menus, preserved tissue samples in 95% ethanol, extracted the genomic DNA, amplified and sequenced a portion of the mtDNA COI gene, and identified the resulting sequence to known fish sequences from the National Center for Biotechnology Information nucleotide database. We compared DNA results with the U.S. Food and Drug Administration (FDA) list of acceptable market names and retail names. We considered sushi‐sample labels that were inconsistent with FDA names mislabeled. Sushi restaurants had a consistently high percentage of mislabeling (47%; 151 of 323) from 2012 to 2015, yet mislabeling was not homogenous across species. Halibut, red snapper, yellowfin tuna, and yellowtail had consistently high (<77%) occurrences of mislabeling on menus, whereas mislabeling of salmon and mackerel were typically low (>15%). All sampled sushi restaurants had at least one case of mislabeling. Mislabeling of sushi‐grade fish from high‐end grocery stores was also identified in red snapper, yellowfin tuna, and yellowtail, but at a slightly lower frequency (42%) than sushi restaurants. Despite increased regulatory measures and media attention, we found seafood mislabeling continues to be prevalent.     

The clinical impact of the first-trimester nuchal translucency between the 95th–99th percentiles

Objectives

To evaluate the clinical significance of nuchal translucency (NT) between the 95th–99th percentile in terms of typical and atypical chromosomal abnormalities (ACAs), associated fetal congenital defects and postnatal outcome.

Methods

A retrospective cohort study of fetuses with NT between the 95th–99th percentile. Data regarding the rate of associated fetal defects, genetic abnormalities and postnatal outcome were collected.

Results

A total of 306 cases of fetuses with an NT between the 95th–99th percentiles were included. The overall rate of genetic abnormalities was 12.1% (37/306). Chromosomal abnormalities were found in 10.1% (31/306) of cases and 2% were ACA (6/306). Within this group, two were pathogenic Copy Number Variants (CNVs) and four were single gene disorders. The overall rate of fetal congenital defects was 13.7% (42/306). All ACAs were found in fetuses with congenital defects. Postnatally, a new diagnosis of a single gene disorder was made in 0.85% of cases (2/236).

Conclusions

The presence of an NT between the 95th–99th percentiles carries a 10-fold increased risk of fetal defects, representing an indication for referral for a detailed fetal anatomy evaluation. The risk of ACA is mainly related to the presence of fetal defects, irrespective of the combined test risk.